Diabetes in Pregnancy Updates: July 2025
Hello,
Welcome to the July edition of the Diabetes in Pregnancy Study Group of North America newsletter.
Below you'll find a round-up of six recently published studies that we think are particularly noteworthy. We hope you'll find our short, to-the-point synopses helpful.
If you have news to share with others who study diabetes in pregnancy, including upcoming papers you would like to see included in our round-ups, please submit them here.
If you haven't already, make sure to register for our 2025 Diabetes in Pregnancy Conference, From Lab to Labor: Advancing Diabetes Care.
There are still 31 days until the deadline to submit abstracts for our conference. Learn more and submit your work here.
Diabetes in Pregnancy News
Diabetic Ketoacidosis
Pregnancy Outcomes Following Diabetic Ketoacidosis: A Systematic Review
Cozzi-Glaser GD, et al. Am J Obstet Gynecol MFM. 2025 May
This systematic review evaluates maternal and neonatal outcomes following diabetic ketoacidosis (DKA) in pregnancy—a rare but serious complication affecting 0.2–3% of pregnancies with pregestational diabetes—and finds a paucity of high-quality publications on pregnancy outcomes...
Technology
Effect of Automated Insulin Delivery Using Hybrid Closed Loops in the Preconception, Peripartum and Postnatal Periods for Women with Type 1 Diabetes
Jones C, et al. J Diabetes Sci Technol. 2025 May
This single-center, retrospective observational study evaluated the impact of hybrid closed-loop (HCL) insulin delivery systems on glycemic control in women with type 1 diabetes (T1D) during preconception, pregnancy, and postnatal periods. Conducted at the University Hospitals of Leicester NHS Trust, the study included 47 women who initiated HCL preconception and 43 who used HCL during pregnancy...
Education
Impact of Maternal Education on Perinatal and Maternal Outcomes in Women with a History of Gestational Diabetes
Collazo Melian K, et al. Cureus. 2025 Apr
This retrospective cohort study investigated the association between parental education and adverse perinatal and maternal outcomes in women with gestational diabetes mellitus (GDM) in the United States. Using data from the National Vital Statistics System-Natality (NVSS-N)...
Genetics
GLP-1R Polymorphisms Modify the Relationship Between Exposure to Gestational Diabetes and Offspring BMI Growth: The EPOCH Study
Harrall KK, et al. Diabetes Care. 2025 Jul
This study investigates whether common polymorphisms in the glucagon-like peptide-1 receptor gene (GLP-1R) modify the relationship between in utero exposure to gestational diabetes mellitus (GDM) and offspring BMI growth and glucose-insulin homeostasis...
Social Determinants of Health
Neighbourhood Deprivation and Gestational Diabetes Mellitus in Arizona from the AzPEARS Study
Parra KL, et al. Paediatr Perinat Epidemiol. 2025 May
This population-based study investigates the association between neighborhood deprivation and gestational diabetes mellitus (GDM) risk in Arizona using data from the AzPEARS study (2014–2020). The analysis included 481,113 singleton live births...
Treatment
The Impact of Metformin on Placental Ageing in Humans and Mice
Hattersley GJ, et al. J Physiol. 2025 Jun
This study investigated whether metformin influences placental ageing in pregnancies affected by maternal obesity. Placental ageing, characterized by telomere shortening, fibrosis, calcification, and transcriptomic changes, is accelerated in adverse pregnancy outcomes such as pre-eclampsia and fetal growth restriction. Given metformin’s proposed anti-ageing properties...
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